Exploring white matter microstructural alterations in mild cognitive impairment: a multimodal diffusion mri investigation utilizing diffusion kurtosis and free-water imaging

HIGHLIGHTS

• What: This study assessed white matter microstructural differences between a cohort of individuals with MCI and an age-matched group of cognitively normal individuals (CN), utilizing data from the Alzheimer`s Disease Neuroimaging Initiative (ADNI) database (Petersen et_al, 2010).1 This study utilized three distinct dMRI techniques-free-water DTI, kurtosis imaging, and mean signal diffusion kurtosis imaging (MSDKI)-to investigate MCI. The free water elimination model aims to mitigate the negative impact of CSF partial volume effects on diffusion measurements (Hoy et_al, 2014). In this study, the computation of FWI-related metrics, including fractional anisotropy (fw . . .
  

   

  

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