Expression of amyotrophic lateral sclerosis-linked sod1 mutant increases the neurotoxic potential of microglia via tlr2*

HIGHLIGHTS

• who: Yang Liu from the Yang Liu1, Wenlin Hao, Alik Dawson, Shirong Liu, and Klaus Fassbender From the Department of Neurology, University of the Saarland, Homburg/Saar, Germany Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease, in which activated microglia overexpressing ALS-linked , mutants (mSOD1) are known to contribute to neuronal deathHowever, it is unclear how m, expression affects micoglial activation and subsequently damages neurons. In this study, we created mSOD1-overexpressing , microglial cell lines. Following TLR2, but not , stimulation, we observed that overexpression of human , G A, L Q, or G V mutant, as . . .
  

   

  

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