Expression of dystrophin dp71 splice variants is temporally regulated during rodent brain development

HIGHLIGHTS

• What: The authors characterized the expression of Dp71 isoforms during fetal (E10.5 E15.5) and postnatal (P1 P7 P14 P21 and P60) mouse and rat brain development. In the adult cerebellar and hippocampal samples, however, the relative levels of expression of Dp71 isoforms were different if the authors compare nanopore sequencing and cloning methods. The authors show that these multiple Dp71 isoforms are expressed in the hippocampus, neocortex, and cerebellum, which are target brain structures involved in the cognitive impairments reported in DMD patients and in a mouse model lacking Dp71 . While the Dp71d group of . . .
  

   

  

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