Expression of herpes simplex virus thymidine kinase/ganciclovir by rna trans-splicing induces selective killing of hiv-producing cells

HIGHLIGHTS

• who: Carin K. Ingemarsdotter from the s Hospital University of have published the Article: Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells, in the Journal: (JOURNAL)
• what: Using the approach , the authors confirmed successful RNA trans-splicing in six of ten designed constructs demonstrating use of the HIV donor site D4 and acceptor sites A3, A5, A7, and A8, all of which were confirmed by PCR and sequencing.
• future: The future work will focus on targeting latent transcripts which may contain the . . .
  

   

  

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