Extended interaction networks with hcv protease ns3-4a substrates explain the lack of adaptive capability against protease inhibitors

HIGHLIGHTS

• who: Georg Dultz from the (UNIVERSITY) have published the article: Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors, in the Journal: (JOURNAL) of April/16,/2020
• what: The authors aimed to identify PI resistance-associated amino_acid substitutions in NS3-4A that lead to high replicative fitness and potentially confer a general drug resistance phenotype to the virus . Fitness compensation by a second-site mutation in the HCV protease NS3-4A, as the authors show here, has not been noted previously . In line with these findings . . .
  

   

  

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