HIGHLIGHTS
SUMMARY
Globally, antibioticresistant pathogens are responsible for approximately 700,000 deaths/year, and 10 million deaths/ year are expected by 2050, a number greatly exceeding deaths from cancer (O`Neill, 2014; de Kraker et_al, 2016; Aslam et_al, 2018). Among the pathogens with growing multidrug resistance, the WHO included ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) against which new antibiotics are urgently needed (World Health Organization, 2017; De Oliveira et_al, 2020; Ma et_al, 2020). Efforts are now focusing on natural products, considered extremely interesting and promising for the . . .
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