Extracellular acidosis is a novel danger signal alerting innate immunity via the nlrp3 inflammasome

HIGHLIGHTS

• who: Kristiina Rajamäki from the (UNIVERSITY) have published the Article: Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome, in the Journal: (JOURNAL) of May/10,/2013
• what: The authors show that low pH, which frequently occurs at sites of inflammation and ischemia, represents a novel danger signal alerting the innate immunity.
• how: The results showed that the measured IL-1␤ response to CHC at pH 7.0 was 1.8-fold compared with the summed one indicating marked synergy between these two inflammasome activators (Fig 6A . . .
  

   

  

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