Extracellular histone release by renal cells after warm and cold ischemic kidney injury: studies in an ex-vivo porcine kidney perfusion model

HIGHLIGHTS

• who: Tim C. van Smaalen and collaborators from the Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands, Department have published the paper: Extracellular histone release by renal cells after warm and cold ischemic kidney injury: Studies in an ex-vivo porcine kidney perfusion model, in the Journal: PLOS ONE of 17/Dec/2022
• what: The clinical introduction of NMP makes the findings relevant for transplant immunology, because the authors show that histones are not only more cytotoxic at higher temperatures, but their presence is more pronounced after prolonged warm perfusion.
• how . . .
  

   

  

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