Extracellular vesicle treatment alleviates neurodevelopmental and neurodegenerative pathology in cortical spheroid model of down syndrome

HIGHLIGHTS

  • who: Natalie Baker Campbell and colleagues from the Department of Anatomy and Neurobiology, Boston University Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, USA have published the research: Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome, in the Journal: (JOURNAL)
  • what: The authors evaluated the therapeutic effect of MSC-EVs in a cortical spheroid (CS) model of DS generated from patient-derived induced pluripotent stem cells (iPSCs). The gene dosage effect of Amyloid precursor protein (APP), one of the HAS21 genes, is considered one of the . . .

     

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