Extracellular vesicles from focal segmental glomerulosclerosis pediatric patients induce stat3 activation and mesangial cell proliferation

HIGHLIGHTS

  • who: Naile T. Pekkucuksen and colleagues from the Division Pediatric Nephrology, Department of Pediatrics, University of Florida, Gainesville, Florida, United have published the Article: Extracellular vesicles from focal segmental glomerulosclerosis pediatric patients induce STAT3 activation and mesangial cell proliferation, in the Journal: PLOS ONE
  • what: Motivated by this, the authors provide insight into a putative mechanism by which EVs released during pediatric FSGS contribute to changes at the glomerular level. The authors showed that STAT-3 activation drives proliferation of mesangial cells.
  • how: The authors compared both groups based on demographics blood work . . .

     

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