Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells

HIGHLIGHTS

SUMMARY

MFI results were normalized to the untreated cells. s MDM2 mRNA decay in BM-MSCs after Actinomycin D treatment demonstrating comparable mRNA levels in the presence of either EV-chromatin, EV-DNA, or empty polymersomes. t Relative expression level of p53 target genes after treatment with 5 µM of Siremadlin. S100 proteins interfere with different regulators of cell proliferation and differentiation, including p53, that control the integrity and survival of hematopoietic and mesenchymal stem_cells in the BM7,8. Physiologically, hematopoietic and mesenchymal stem_cells receive multiple signals from BM stroma, where p53 plays a crucial . . .

 



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