Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer?

HIGHLIGHTS

  • who: Eric Seidel from the University of Medicine Cologne (CMMC), Cologne, Germany have published the Article: Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer?, in the Journal: (JOURNAL) of 24/06/2022
  • what: Thereby, in the context of tumor evolution and repeated selective sweeps, the authors propose a concept of cell death pathway plasticity in time in which the inactivation of one cell death pathway will create collateral selective pressure via another (Fig 2). While this approach has yielded many valuable insights and has helped to improve treatment prognosis in many . . .

     

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