Extrinsic stabilization of antiviral ace2-fc fusion proteins targeting sars-cov-2

HIGHLIGHTS

• who: Hristo L. Svilenov from the Department Technical University Garching, Germany have published the research: Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2, in the Journal: (JOURNAL) of 14/Dec/2022
• what: The authors aimed to characterize the structure and conformational dynamics of ACE2-Fc in solution. The authors analyzed the solution structure of an ACE2-IgG4-Fc and show that the conformational stability of the ACE2-domain is lower than that of the Fc-moiety. The model was glycosylated following the pattern proposed by Mehdipour and Hummer37 indicated as HT1 . . .
  

   

  

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