Ezh2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells

HIGHLIGHTS

• What: The authors propose that direct transcriptional modulation of the mesenchymal gene_expression programme by PRC2 is a conserved molecular mechanism across different types of carcinomas that contributes to equipping cells with the plasticity required for efficient cell dissemination. EZH2 represses mesenchymal genes in breast carcinoma cells To analyse the function of EZH2 in breast cancer, the authors focused on the human MCF-7 cell line because it is a well-established system to study the molecular basis of metastasis in breast adenocarcinomas. The authors propose that low activity of EZH2 protein in EED-depleted HMLER cells promotes . . .
  

   

  

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