HIGHLIGHTS
- who: Djamila Chemlal from the CNRS University of Universitaire de France have published the article: EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma, in the Journal: (JOURNAL) of 12/07/2023
SUMMARY
Remarkably, the authors also identified a negative association between H3K27me3 level at the CD38 promoter and the relative CD38 mRNA and protein expression levels, particularly in JJN-3, XG-20 and AMO-1, consistent with a role of EZH2 in CD38 expression modulation (Fig 1C). We, therefore, aimed to validate in_vitro the role of EZH2 . . .
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