HIGHLIGHTS
SUMMARY
YxxΦ and_[DE] xxxL[LI], where x can be any residue and Φ is a hydrophobic amino_acid, are the two most common motifs for AP2 recognition. FACI is a small protein with around 115 amino_acids and is abundantly expressed in the liver and small intestine. Drug treatment AML12-mRuby2-FACI cells were cultured in doxycycline-containing media for one day to induce the expression of mRuby2-FACI. To the contrary, a remarkable spike of LDL uptake was observed in stable AML12-V5-FACI cells overexpressing FACI (Fig 7C). The 6-week-old mice (male) were . . .
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