Factorial mendelian randomization: using genetic variants to assess interactions

HIGHLIGHTS

• who: Key Messages et al. from the C The Author(s) Published by Oxford University Press on behalf of the International Epidemiological AssociationUniversity of Cambridge, Cambridge, UK have published the article: Factorial Mendelian randomization: using genetic variants to assess interactions, in the Journal: (JOURNAL)
• what: The authors propose two-stage least squares methods using all available genetic variants and their interactions as instrumental variables and using continuous genetic scores as instrumental variables rather than dichotomized scores. All four approaches provided unbiased estimates of the interaction effect in all scenarios, with coverage for the 95% confidence . . .
  

   

  

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