Familial alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues

HIGHLIGHTS

• who: Sujan Devkota from the Sujan Devkota1, Todd DWilliams2, and Michael S. Wolfe1, * From the Department of Medicinal Chemistry, Mass Spectrometry Laboratory, University of Kansas, Lawrence, Kansas, USA Edited by Paul Fraser have published the paper: Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues, in the Journal: (JOURNAL) of November/30,/2020
• how: For substrate the authors used C100-FLAG a standard recombinant C99-based substrate with an N-terminal methionine and a C-terminal FLAG epitope tag. The authors conducted such a . . .
  

   

  

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