Fancd2 maintains replication fork stability during misincorporation of the dna demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine

HIGHLIGHTS

• who: Maru00eda Josu00e9 Peu00f1a-Gu00f3mez from the (UNIVERSITY) have published the research work: FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2u2019-deoxycytidine and 5-hydroxymethyl-2u2019-deoxyuridine, in the Journal: (JOURNAL) of 25/Oct/2021
• how: Data was analyzed using Agilent MassHunter software.

SUMMARY

In agreement with this, 5hmdC exposure unveiled a fork defect in Parp1+/+ wild_type cells compared to Parp1-/- (Fork speed Parp1+/+ unt 1.27 Kbp/min Parp1+/+ 5hmdC 0.96 Kbp/min; Parp1-/- unt 1.22 Kbp/min; Parp1-/- 5hmdC 1 . . .

 



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