Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but mycobacterium tuberculosis counteracts this process via hif-1α activation

HIGHLIGHTS

• who: Melanie Genoula et al. from the School, UNITED STATES (INEI), ANLIS "Carlos GMalbrán, Buenos Aires, Argentina have published the research: Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation, in the Journal: (JOURNAL)
• what: The authors aimed to elucidate whether distinct macrophage activation states exposed to a tuberculosis-associated microenvironment or directly infected with Mtb can form FM. This study provides key insights into macrophage metabolism and pathogen subversion strategies. The authors demonstrated that IL-4/STAT6-driven FAO prevents FM . . .
  

   

  

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