Fbp1/mir-24-1/enhancer axis activation blocks renal cell carcinoma progression via warburg effect

HIGHLIGHTS

  • who: Dongen Ju from the Medical University of South Carolina, United States have published the article: FBP1/miR-24-1/enhancer axis activation blocks renal cell carcinoma progression via Warburg effect, in the Journal: (JOURNAL)
  • what: The work demonstrated that overexpression of miR-24-1 can activate FBP1 to block RCC proliferation and metastasis , shedding a light on the unconventional role of miRNAs in malignancies. The work showed that deletion of miR-24-1 reduces enhancer activity in RCC, nevertheless, enhancer inactivation leads to low expression of FBP1, which in turn promoted the Warburg effect . . .

     

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