Fbxo9 mediates the cancer-promoting effects of znf143 by degrading fbxw7 and facilitates drug resistance in hepatocellular carcinoma

HIGHLIGHTS

  • who: Zhenyu Wang from the State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer have published the research work: FBXO9 Mediates the Cancer-Promoting Effects of ZNF143 by Degrading FBXW7 and Facilitates Drug Resistance in Hepatocellular Carcinoma, in the Journal: (JOURNAL)
  • what: The authors report that FBXO9, under the control of ZNF143, ubiquitylates and degrades FBXW7 and facilitates HCC proliferation, metastasis, and drug resistance. The authors demonstrated that FBXO9 directly interacted with . . .

     

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