Fbxw7 inactivation induces cellular senescence via accumulation of p53

HIGHLIGHTS

• who: Longyuan Gong from the Fbxw7+/- mice were generated by crossing Fbxw7fl/fl (Jackson laboratory, Stock No:, ) mice with Vasa-Cre (Jackson laboratory, Stock No:, ) transgenic miceMice were genotyped using the following primers to detect floxed Fbxw, (, bp), deleted Fbxw, (, bp), and WT (, bp): Fbxw7-cKO-F:, u2032-ATT GAT ACA AAC TGG AGA CGA GG-3u2032 have published the research: FBXW7 inactivation induces cellular senescence via accumulation of p53, in the Journal: (JOURNAL) of 11/04/2022
• what: The authors report that FBXW7 inactivation readily induces cellular senescence in p53 wild-type cells, but . . .
  

   

  

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