Fer governs mtorc1 regulating pathways and sustains viability of pancreatic ductal adenocarcinoma cells

HIGHLIGHTS

• What: The authors show that the intracellular tyrosine kinase-Fer sustains key regulatory processes and signaling pathways, some of which serve as downstream effectors of oncogenic KRAS in PDAC tumors. The authors show here that E260 leads to the activation of AMPK in PDAC cells. The authors show here for the first time that the expression level of Fer is positively correlated, in PDAC tumors but not in normal pancreatic tissues, to the elevated expression of the downstream effector and regulator of mTORC1 -LARP1. The authors show in this work that a Fer inhibitor can simultaneously target . . .
  

   

  

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