Ferritin heavy chain binds peroxiredoxin 6 and inhibits cell proliferation and migration

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SUMMARY

    The authors demonstrated that the FTH1/PRDX6 interaction also occurred in NCI-H460 cells and investigated the functional role of this binding in cell migration and proliferation. HEK-293T_cells, transfected with an empty vector, were used as control. Among the proteinsphysical already known to interact with FTH1,cells NCOA4 has been transfected identified, and the To assess PRDX6-FTH1 interaction, HEK-293T transiently interaction has also been confirmed by immunoprecipitation (data not shown). FTH1/PRDX6 Interaction in HEK-293T and NCI-H460 Cells To assess PRDX6-FTH1 physical interaction, HEK-293T_cells transiently transfected with . . .

     

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