Fgf19/fgfr4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis

HIGHLIGHTS

  • who: Liwei Lang from the Department of Oral Biology and Diagnostic Sciences, Dental College of, Augusta University, , th Street, Augusta, GA, USA have published the paper: FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis, in the Journal: (JOURNAL)
  • what: The authors report for the first time that MT has the ability to induce ER stress-associated FGF19 upregulation in a dose-dependent fashion, which in turn activates FGFR4-Vimentin invasive signaling in HNSCC cells. The experiment was modified and carried out as the authors previously described . . .

     

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