Fibrinogen function achieved through multiple covalent states

HIGHLIGHTS

  • who: Diego Butera from the Centre University of Sydney, Sydney, NSW, Australia have published the article: Fibrinogen function achieved through multiple covalent states, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • what: The authors examine the blood protein fibrinogen, which plays a critical role in arresting bleeding (hemostasis) and obstruction of blood vessels (thrombosis) by bridging platelets at sites of vessel injury. The authors report that fibrinogen exists in multiple disulfide-bonded states in the circulation that are important for the function of the protein.
  • how: Data were analyzed using Mascot Daemon (Version 2 . . .

     

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