Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular prp release*

HIGHLIGHTS

• who: Mathieu Marella from the (UNIVERSITY) have published the research: Filipin Prevents Pathological Prion Protein Accumulation by Reducing Endocytosis and Inducing Cellular PrP Release*, in the Journal: (JOURNAL) of April/24,/2002
• what: The authors report that copper stimulates the endocytosis of PrP-sen via a caveolin-dependent pathway in both microglia and neuroblastoma cells. The authors demonstrate that filipin is a potent inhibitor of PrP-res formation into chronically infected neuroblastoma cells. The authors demonstrate that the binding of a radiolabeled PrP-recognizing monoclonal antibody can be used to assess quantitatively internalization of mem . . .
  

   

  

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