First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (dxps) from mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

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• who: Robin M. Gierse from the Helmholtz Institute Saarland University Campus Building, Saarbru00fccken, Germany. have published the paper: First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization, in the Journal: Scientific Reports Scientific Reports
• what: In the recent Article, the authors showed that the truncation of a nonconserved loop not visible in the structures of the DXPS enzyme of D. radiodurans (drDXPS) improved the crystallization of this u00adtarget27. The work proposes a different stabilization mechanism of the enamine intermediate in MtDXPS when . . .
  

   

  

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