Fisetin, a 3,7,3′,4′-tetrahydroxyflavone inhibits the pi3k/akt/mtor and mapk pathways and ameliorates psoriasis pathology in 2d and 3d organotypic human inflammatory skin models

HIGHLIGHTS

• who: Jean Christopher Chamcheu et al. from the School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at LA, USA have published the research: Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models, in the Journal: (JOURNAL)
• what: The authors assessed the effect of fisetin in a psoriasis model, and demonstrated that at low (micromolar) concentrations fisetin inhibited intracellular PI3K/Akt/mTOR and MAPK signaling components and normal human epidermal keratinocyte (NHEK . . .
  

   

  

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