HIGHLIGHTS
- who: Shogo Ijima and colleagues from the Yale University, United States have published the research work: Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis, in the Journal: (JOURNAL)
- what: Although various senescence-related genes and proteins are involved in chronic inflammation in multiple organs, the authors focused on p15INK4B, which is upregulated during TGF-brelated cell senescence . p15INK5B, encoded by CDKN2B, is located near CDKN2A, which is another member of the INK4 family. p15INK4B binds to CDK4 and CDK6, preventing their binding to cyclins, thereby inhibiting . . .
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