Flagellin from pseudomonas aeruginosa modulates sars-cov-2 infectivity in cystic fibrosis airway epithelial cells by increasing tmprss2 expression

HIGHLIGHTS

• who: Manon Ruffin et al. from the Emory University, United States have published the research work: Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression, in the Journal: (JOURNAL) of October/30,/2021
• what: The authors showed that exposure of AECs to flagellin from P. aeruginosa induces an increase in TMPRSS2 expression, which is dependent on TLR5 and p38 MAPK activation.
• how: The results showed that flagellins from P. aeruginosa and S. Typhimurium which were able to induce IL-8 production (Supplementary Figure . . .
  

   

  

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