Fluorescently tagged nanobodies and nanobret to study ligand-binding and agonist-induced conformational changes of full-length egfr expressed in living cells

HIGHLIGHTS

• who: Dehan Comez and colleagues from the Pasteur Institute of Iran, IranDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of have published the article: Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells, in the Journal: (JOURNAL)
• what: This approach has revealed nanobodies that bind to a similar site to EGF on the receptor and others that bind to EGFR but do not compete for EGF binding and are nonactivating . This work has shown that single ligand occupied asymmetric . . .
  

   

  

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