Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination

HIGHLIGHTS

  • who: Carsten Sven Kramer from the , Heidelberg, Germany have published the article: Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination, in the Journal: (JOURNAL)
  • what: The authors show with the model substrate that the linker combination is capable of yielding the desired silicon fluoride in amounts sufficient for biological studies in animals or humans under standard fluorination conditions that may also be transferred to a radiolabelling setting. The authors propose a solid phase method in combination with a fluorophilic linker.
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