Folate-functionalization enhances cytotoxicity of multivalent dna nanocages on triple-negative breast cancer cells

HIGHLIGHTS

  • who: Valeria Unida and colleagues from the Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, Rome, Italy have published the research: Folate-Functionalization Enhances Cytotoxicity of Multivalent DNA Nanocages on Triple-Negative Breast Cancer Cells, in the Journal: Pharmaceutics 2022, 2610 of /2022/
  • what: The authors demonstrate that the presence of as a targeting ligand increases the efficiency in miR-21 silencing compared to functionalized with AS1411. The authors focused on the u03b1-isoform of the folate receptor (u03b1FR) since it is a tumor-associated antigen overexpressed in many tumors and largely . . .

     

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