Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly

HIGHLIGHTS

• who: Jemil Ahmed from the Molecular and Cellular Biophysics Program, University of have published the Article: Foldamers reveal and validate therapeutic targets associated with toxic u03b1-synuclein self-assembly, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The binding_sites of SK-129 on u03b1S contain lysine and hydrophobic residues; therefore, the authors propose that the carboxylic acid and the propyl side chains of SK-129 are involved in binding interactions with lysine and hydrophobic residues of u03b1S. | https://doi.org/10.1038/s41467-022-29724-4 Effect of SK-129 on u03b1S conformation. The study . . .
  

   

  

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