HIGHLIGHTS
- who: Mohey Eldin M. El Shikh from the Civili and University of Brescia, Brescia, Italy have published the research: Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis, in the Journal: (JOURNAL)
- what: The authors show that pericyte-derived CXCL13 promotes B cell chemotaxis upstream of FDCs, and that activated RA synovial fibroblasts retain ICs and, in an FDC-like manner, induce T_cell independent B cell activation and Ig secretion. The authors systemically investigated the role of PDGF-BB and TNF-u03b1/LT-u03b2 in FDC development and pathotype differentiation . . .
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