HIGHLIGHTS
- who: Igor Koval from the InstitutFranceUniversity of have published the Article: Forecasting individual progression trajectories in Huntington disease enables more powered clinical trials, in the Journal: Scientific Reports Scientific Reports
- what: The authors propose here to use a disease modeling technique, called disease course mapping, to enrich the trial population in participants likely to exhibit progression of a given endpoint during trial. Despite the regulatory appeal of a functional readout, the analysis shows that TFC is an inappropriate endpoint for early-stage trials. | 12:18928 | 3 Vol.:(0123456789) HD COURSE MAP captures differences in the . . .
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