HIGHLIGHTS
SUMMARY
Most of these responses are orchestrated at the transcriptional level, with the Hypoxia Inducible Factors (HIFs) being the main drivers of the hypoxic gene_expression pattern. The first analysis of this type, based on the analysis of gene profiles generated by means of DNA microarrays, produced the first list of genes universally induced by hypoxia and revealed that the set of genes induced by hypoxia were more conserved than those repressed. Among the various meta-analysis methods applicable to transcriptomic data, the authors employed a model that combines the effect sizes (log fold change of . . .
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