HIGHLIGHTS
SUMMARY
Caveolae are flask-shaped invagination of the plasma_membrane of mammalian cells of 50 to 100 nm of diameter. Caveolae are essentially linked to the presence in the plasma_membrane of the caveolin proteins, mainly caveolin-1 and -3, and cavins (cavin1-4). The protein undergoes multiple modifications during membrane trafficking from synthesis site to plasma_membrane, including oligomerization which appeared shortly after biosynthesis and association with lipids. The location of these vesicles beneath the plasma_membrane indicates that they are likely formed from it, or at least from certain sub-domains of the bacterial plasma_membrane since they . . .
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