HIGHLIGHTS
- who: October and colleagues from the University of Tsukuba, Japan have published the article: FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis, in the Journal: (JOURNAL)
- what: The authors show that PPP activity and nucleotide biosynthesis are indispensable for erythroid differentiation of human HE cells, which is controlled by AKT and NRF2. As the GPA marker appears late during the differentiation and does not inform on the maturity of the erythroid cell, the authors focused on the expression of CD71 (transferrin receptor) which is expressed at an earlier stage on erythroid cells (Hu . . .
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