HIGHLIGHTS
SUMMARY
It remains unknown how FOXQ1 regulates gene_expression. Genetic disruption of the FOXQ1-RbBP5 interaction or pharmacologic targeting of KMT2/MLL recruitment inhibits FOXQ1-dependent gene_expression, EMT, and in_vivo tumor progression. The authors confirmed that FOXQ1 binds the MLL core complex (RbBP5, WDR5, and ASH2L) in human mammary epithelial_cells with ectopic FOXQ1 expression (HMLE/FOXQ1) (Fig 1b). The specificity of the FOXQ1 antibody was further validated by RbBP5-IP in MDA-MB231 cells with FOXQ1 knockdown (Supplementary Fig 1f). FOXQ1 and the MLL core complex co-regulate gene targets with critical EMT functions To assess . . .
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