Frank-starling mechanism, fluid responsiveness, and length-dependent activation: unravelling the multiscale behaviors with an in silico analysis

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  • who: Sarah Kosta and Pierre C. Dauby from the GIGA-In Silico Medicine, University of Liège, Liège, Belgium have published the research: Frank-Starling mechanism, fluid responsiveness, and length-dependent activation: Unravelling the multiscale behaviors with an in silico analysis, in the Journal: (JOURNAL) of October/11,/2021
  • what: The authors show however that the cellular force increase is not enough to explain the cardiac response to rapid changes in preload. The authors investigated the relationship between length-dependent activation (LDA) the 1 / 23 __NEWPAGE__PLOS COMPUTATIONAL BIOLOGY f Crossbridges attachment rate; gd Crossbridges . . .

     

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