Friction-driven membrane scission by the human escrt-iii proteins chmp1b and ist1

HIGHLIGHTS

• who: A. King Cada and colleagues from the (UNIVERSITY) have published the research: Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1, in the Journal: PNAS of November/25,/2022
• what: The authors show that membrane scission does occur under dynamical tube extension, showing that friction-driven scission is operative under these conditions, consistent with a biological role for CHMP1B and IST1 in tubular endosome severing. The authors focused on the VPS4B isoform for all the studies since the authors found that it is easier to express and purify. The study . . .
  

   

  

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