From the tyrosine hydroxylase hypothesis of parkinson’s disease to modern strategies: a short historical overview

HIGHLIGHTS

  • who: Wolf-Dieter Rausch from the Institute of Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria have published the paper: From the tyrosine hydroxylase hypothesis of Parkinsonu2019s disease to modern strategies: a short historical overview, in the Journal: (JOURNAL)
  • what: In detail, the paper describes the isolation of enzyme, necessity for its cofactors tetrahydrobiopterin and ferrous iron and its presence in different tissues as adrenal medulla, spleen, and various brain areas of laboratory animals. An early study was carried out to investigate whether 3-methyladenine, an autophagy inhibitor, can modulate the effects of rotenone . . .

     

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