SUMMARY
Copyright: Systemic sclerosis (scleroderma, SSc) is one of the most challenging rheumatic diseases, characterized by vasculopathy, dysregulation of the immune_response, and progressive tissue fibrosis affecting the skin, lungs, heart, digestive tract, and kidneys. To date, it is considered incurable and carries the highest cause-specific mortality of all connective tissue diseases. In spite of a large number of clinical trials and the progress made in their design over the last decade, no approved disease-modifying therapies exist for SSc to date. In their review article, Papadimitriou et_al focus on the contribution of the innate and acquired immune . . .
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