HIGHLIGHTS
- who: Sameer Kulkarni from the (UNIVERSITY) have published the paper: FULL PAPER, in the Journal: (JOURNAL)
- what: The authors proposed an effective solution to this synthetic bottleneck through the use of the alkyl thiol additive trifluoroethanethiol (TFET), which has been shown to facilitate native chemical ligation reactions at Cys and other thiolderived amino_acid at similar rates to the gold standard thiol additives e_g MPAA.
SUMMARY
Native chemical ligation is a chemoselective reaction that enables the fusion of a peptide bearing a C-terminal thioester with a peptide possessing an N-terminal . . .
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