HIGHLIGHTS
- who: Vincent Zecchini from the (UNIVERSITY) have published the research: Fumarate induces vesicular release of mtDNA to drive innate immunity, in the Journal: (JOURNAL) of 24/01/2022
- what: The authors show that loss of FH leads to early alterations of mitochondrial morphology and the release of mitochondrial DNA (mtDNA) into the cytosol, where it triggers the activation of the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING)-TANK-binding kinase 1 (TBK1) pathway and stimulates an inflammatory response that is also partially dependent on retinoic-acidinducible gene I (RIG-I). Mechanistically, the . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.