Function of kcnq2 channels at nodes of ranvier of lumbar spinal ventral nerves of rats

HIGHLIGHTS

• who: Sotatsu Tonomura from the (UNIVERSITY) have published the article: Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats, in the Journal: (JOURNAL)
• what: The authors show that depolarizing voltages evoke large non-inactivating outward currents at NRs which are partially inhibited by KCNQ channel blocker linopirdine and potentiated by KCNQ channel activator retigabine. The authors aimed to address these questions by using ex vivo lumbar spinal ventral nerve preparation and whole-cell patch-clamp recordings at NRs. The authors demonstrate that functional KCNQ2 channels are present at NRs . . .
  

   

  

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