HIGHLIGHTS
- who: Isabel Hinsenkamp from the (UNIVERSITY) have published the research: Functional antagonism between CagA and DLC1 in gastric cancer, in the Journal: (JOURNAL) of 13/07/2022
- what: The authors propose that loss of the RHOinhibitor DLC1 correlates with H. pylori infection in certain GC subtypes.
SUMMARY
The authors found that (i) CagA physically interacted with DLC1, (ii) DLC1 inhibited intracellular CagA signalling, and_(iii) CagA downregulated transcription from DLC1v1/4 promoters, proposing DLC1-mediated inhibition of CagA/RHO signalling as a potential therapeutic target. Compared with epithelial_cells of the non . . .
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